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Translation, Interpreting, Editing/proofreading, Software localization, Voiceover (dubbing), Training
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Specializes in:
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Sample translations submitted: 1
English to Spanish: Lozenges for the treatment of sore throat provide relief of discomfort in cases of oral inflammation. General field: Medical
Source text - English This effect has not been fully explained so far. Here, we have examined the proposition that key components of pharmaceutical preparations for the treatment of sore throat which are routinely regarded antiseptics might have sodium channel- blocking, i.e. local anaesthetic-like effects.
We investigated the effects of hexylresorcinol, amylmetacresol and dichloro- benzylalcoholonvoltage-operatedneuronal(NaV1.2) sodium channels heterologously expressed in HEK 293 cells in vitro.
Hexylresorcinol, amylmetacresol and dichloro-benzylalcohol reversibly blocked depolarisation-induced whole-cell sodium inward currents. The half-maximum blocking concentrations (EC50) at−150 mV were 23.1, 53.6 and 661.6 µM, respectively.
Block induced by hexylresorcinol and amylme- tacresol was increased at depolarised potentials and use-dependent during trains of depolarisations applied at high frequency (100 Hz) indicating that both drugs bind more tightly to inactivated conformations of the channel. Estimates for the inactivated state affinity were 1.88 and 35 µM for hexylresorcinol and amylmetacresol, respectively.
Translation - Spanish Este efecto no se ha explicado completamente hasta ahora. Aquí, hemos examinado la proposición de que los componentes clave de las preparaciones farmacéuticas para el tratamiento del dolor de garganta que se consideran rutinariamente antisépticos podrían tener bloqueo de canales de sodio, es decir, efectos de tipo anestésico local.
Se investigaron los efectos de los canales de sodio neuronales accionados por hexilresorcinol, amilmetacresol y sodio (NaV1.2) operados por diclorobencilalcohol expresados heterologicamente en células HEK 293 in vitro.
El hexilresorcinol, el amilmetacresol y el dicloro-bencilalcohol bloquearon de forma reversible las corrientes internas de sodio de células enteras inducidas por despolarización. Las concentraciones medio-máximas de bloqueo (EC50) a-150 mV fueron 23,1, 53,6 y 661,6 μM, respectivamente.
El bloqueo inducido por hexilresorcinol y amylme-tacresol se incrementó a potenciales despolarizados y dependiente del uso durante los trenes de despolarizaciones aplicadas a alta frecuencia (100 Hz), lo que indica que ambos fármacos se unen más firmemente a las conformaciones inactivadas del canal. Las estimaciones para la afinidad de estado inactivado fueron de 1,88 y 35 μM para hexilresorcinol y amilmetacresol, respectivamente.
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Translation education
Bachelor's degree - Universidad Los Libertadores
Experience
Years of experience: 10. Registered at ProZ.com: Nov 2016.
Across, Adobe Acrobat, Adobe Illustrator, Adobe Photoshop, AutoCAD, Google Translator Toolkit, Microsoft 365, Microsoft Excel, Microsoft Word, Powerpoint
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