This site uses cookies.
Some of these cookies are essential to the operation of the site,
while others help to improve your experience by providing insights into how the site is being used.
For more information, please see the ProZ.com privacy policy.
Open to considering volunteer work for registered non-profit organizations
Rates
General rate: 0.13 EUR per word / 30.5 EUR per hour
Rates per language pair: German to English - Rates: 0.11 - 0.15 EUR per word / 35 - 45 EUR per hour Dutch to English - Rates: 0.11 - 0.15 EUR per word / 35 - 45 EUR per hour English - Rates: 0.11 - 0.15 EUR per word / 35 - 45 EUR per hour
German to English: PAR1 Rezeptoren vermitteln die neuronale Aktivierung durch Biopsieüberstände der Kolonschleimhaut von Patienten mit Reizdarmsyndrom (IBS) aber nicht von Patienten mit Colitis Ulcerosa (CU) General field: Medical Detailed field: Science (general)
Source text - German PAR1 Rezeptoren vermitteln die neuronale Aktivierung durch Biopsieüberstände der Kolonschleimhaut von Patienten mit Reizdarmsyndrom (IBS) aber nicht von Patienten mit Colitis Ulcerosa (CU)
Hintergrund: Mediatoren der Kolonscheimhaut von IBS Patienten aktivieren Neurone des humanen submucösen Plexus. Diese Aktivierung wird überwiegend durch Histamin, Serotonin und Proteasen vermittelt. Für Histamin und Serotonin konnten die beteiligten Rezeptoren identifiziert werden, für die Proteasen bisher nicht. Wir konnten kürzlich zeigen, dass neuronal Proteaseeffekte am menschlichen Darm überwiegend durch den Protease-Aktivierten Rezeptor (PAR) 1 vermittelt werden.
Methode: Daher untersuchten wir in der vorliegenden Arbeit die Wirkung des PAR1 Rezeptorantagonisten SCH79797 (10µM) auf die neuronale Aktivierung durch Schleimhautbiopsieüberstände von 10 Patienten mit IBS (9 IBS-D und 1 IBS-C). Die neuronale Aktivität wurde mittels eines Neuroimaging-Verfahrens unter Verwendung eines spannungssensitiven Farbstoffs (Di-8-ANEPPS) an 233 humanen submucösen Neuronen gemessen. In derselben Weise wurden die Effekte von Kolonschleimhautüberständen von 9 Patienten mit CU in Remission untersucht.
Ergebnisse: Alle IBS Überstände aktivierten die humanen submukösen Neurone (mediane Aktionspotentialfrequenz 2,9Hz, IQR 1,2–5,3Hz; n=142 Neurone). Der PAR1 Rezeptor-antagonist SCH79797 hemmte diese Aktivierung signifikant für jede Probe (Median 0Hz (IQR 0–1,6Hz)). Dies steht in deutlichen Gegensatz zu den Befunden für die entsprechenden Überstände der CU Patienten. Hier konnte die starke nervenaktivierende Wirkung der Überstände nicht durch den PAR1 Rezeptorantagonist gehemmt werden (mediane Aktionspotentialfrequenz 2,4 (IQR 1,7–4,8) vs. 2,4 (IQR 1,3–4,2) Hz, n=91 Neurone).
Schlussfolgerung: Bei IBS scheinen neuronale PAR1 vermittelte Effekte eine wichtige Rolle bei der Aktivierung enterischer Neurone durch mucosale Faktoren zu spielen. Die Ergebnisse sprechen dafür, dass Änderungen im Signalling zwischen der Darmschleimhaut und submukösen Neuronen auch bei CU in Remission existieren. Jedoch ist das Wirkprofil der Mediatoren ein anderes als bei IBS. Für die Behandlung des IBS könnte PAR1 ein attraktives Target darstellen.
(Source: Z Gastroenterol 2012; 50 - K245)
Translation - English PAR1 receptors mediate neural activation by supernatants from colonic biopsy specimens of patients with Irritable Bowel Syndrome (IBS), but not of patients with Ulcerative Colitis (UC)
Background: Mediators released by the colonic mucosa of IBS patients activate neurons in the human submucosal plexus. This activation is predominantly mediated by histamine, serotonin, and proteases. The receptors involved in histamine and serotonin signalling have been identified, but those mediating the effects of proteases have not. We have recently demonstrated that protease-activated receptor 1 (PAR1) mediates the neuronal effects of proteases in the human intestine.
Methods: In the present study, we therefore investigated the effect of the PAR1 receptor antagonist SCH79797 (10 µM) on neuronal activation induced by supernatants from mucosal biopsy specimens obtained from 10 IBS patients (9 IBS-D and 1 IBS-C). Neuronal activity was measured in 233 human submucosal neurons by neuroimaging using the voltage-sensitive dye Di-8-ANEPPS. Likewise, the effect of colonic mucosal biopsy supernatants from 9 UC patients in remission was assessed.
Results: All IBS supernatants activated human submucosal neurons (median frequency of action potential discharge: 2.9 Hz, IQR 1.2–5.3 Hz; n = 142 neurons). The PAR1 receptor antagonist SCH79797 significantly inhibited this activation in each sample (median: 0 Hz [IQR 0–1.6 Hz]). This finding contrasts markedly with the results obtained using the corresponding supernatants from UC patients. In these samples, the potent neuronal activation induced by the supernatants could not be inhibited by the PAR1 receptor antagonist (median frequency of action potential discharge: 2.4 Hz [IQR 1.7–4.8 Hz] vs. 2.4 Hz [IQR 1.3–4.2 Hz]; n = 91 neurons).
Conclusions: In IBS, PAR1-mediated neuronal effects appear to play an important role in the activation of enteric neurons by mucosal factors. The results indicate the presence of alterations in signalling between the intestinal mucosa and submucosal neurons even during remission of UC. However, the mode of action of these mediators differs from that observed in IBS. PAR1 may represent an attractive therapeutic target for the treatment of IBS.
(Source: Z Gastroenterol 2012; 50 - K245)
More
Less
Translation education
PhD - Utrecht University, the Netherlands
Experience
Years of experience: 15. Registered at ProZ.com: Sep 2013. Became a member: Nov 2014.
Medical Translator Specialising in Patient Records (German/Dutch → English)| 10+ Years of Experience | Former Researcher | PhD in Medical Biology
I provide medical record translation from German and Dutch into English, including discharge summaries, diagnostic reports, and clinical documentation for treatment abroad, insurance, and clinical use.
I work mainly in the fields of cardiology, oncology, and surgery—translating medical records and reports, ranging from stent procedures and cardiac interventions to cancer diagnostics and treatment documentation.
Patient records I translate
Medical reports – including hospital discharge summaries, patient records, and electronic health records (EHRs)
Doctor’s letters – referral letters, specialist correspondence, and medical communications
Patient case histories – medical histories, clinical notes, and treatment records
Discharge summaries – hospital discharge reports, post-treatment summaries, and care transition documents
Laboratory test results – blood test reports, diagnostic laboratory results, and clinical test findings
Follow-up and aftercare instructions – post-discharge care plans, recovery guidelines, and outpatient instructions
Specialist strengths
Accurate interpretation of diagnoses, procedures, and specialised terminology
Confident handling of medical abbreviations based on subject-matter expertise
Correct resolution of ambiguities based on clinical context
Clear, professional translations that follow clinical documentation standards
Client benefits at a glance
Fast, flexible service – including quick responses (typically within 30 minutes during working hours), clarification support, integration of additional documents, and the option for urgent same-day delivery
Direct communication – work directly with one dedicated translator, with no agencies or intermediaries involved
Continuity and long-term support – a reliable partner who can follow a patient’s case over time and refer back to earlier translations across multiple documents
Consistency and quality – uniform style and terminology across all translations, with careful attention to client preferences and requirements
If you're looking for a specialist in medical records translation who offers responsive service and, when needed, same-day delivery, feel free to get in touch.
Keywords: medical record translation, patient record translation, medical report translation, discharge summary translation, radiology report translation, pathology report translation, surgical report translation, translate medical records German to English, translate medical records Dutch to English, German to English medical translation. See more.medical record translation, patient record translation, medical report translation, discharge summary translation, radiology report translation, pathology report translation, surgical report translation, translate medical records German to English, translate medical records Dutch to English, German to English medical translation, Dutch to English medical translation, clinical document translation, medical document translation, hospital report translation, medical translation for insurance, medical translation for treatment abroad. See less.
This profile has received 170 visits in the last month, from a total of 123 visitors
Member since Nov '14
Expertise 
