Glossary entry

French term or phrase:

au dernier des termes échu

English translation:

whichever [time interval] is longer

Added to glossary by Anne Schulz
Aug 2, 2012 11:35
11 yrs ago
French term

au dernier des termes échu

French to English Medical Medical: Pharmaceuticals Clinical trial exclusion criteria
This appears as one of the exclusion criteria for a clinical trial:

Prise d'un médicament expérimental au cours des 28 jours précédant la première dose du traitement à l'étude ou depuis une durée équivalent à 5 fois la demi-vie d'élimination avant la première dose du traitement à l'étude (au dernier des termes échu).

I have previously translated this as "whichever is later", but I'm not sure whether this would work here as I don't see how it would be relevant. The exclusion criteria would surely be for both of these circumstances.
Change log

Aug 8, 2012 18:36: Anne Schulz Created KOG entry

Discussion

SJLD Aug 2, 2012:
similar wording http://public.ukcrn.org.uk/search/StudyDetail.aspx?StudyID=2...
Participation in other investigational drug studies, or use of other investigational drugs within one month or five times the half-life of the investigational drug (whichever is longer) prior to baseline visit

So, if five times the half-life is longer than one month, then that is the criterion to be used. Let's say five times the half-life is 6 weeks. In that case, the subject would be excluded if the drug had been taken within 6 weeks and not one month.
It's a little confusing at first but perfectly logical when you think about it :-)
Bertrand Leduc Aug 2, 2012:
I would go with your suggestion: " Whichever is later", as the "ou" suggests that it is one or the other.

Proposed translations

+2
1 hr
Selected

whichever time interval is longer/whichever dates further back

equivalent to "whichever occurs first/last", but referring to a time interval rather than a time point here
Peer comment(s):

agree SJLD : whichever is longer http://www.google.com/search?q= five times half-life "whiche...
7 hrs
agree B D Finch
20 hrs
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "Thank you all for the clarification!"
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