clue
https://www.bmj.com/content/362/bmj.k2738
The importance attached to latency is reflected in a major push from research funding agencies to understand the biology and epidemiology of latent TB infection and to develop drugs that specifically treat latent infection, aiming for global TB eradication (supplementary box 2). Multiple longitudinal epidemiological studies, however, show that the majority of TB disease manifests soon after infection, with disease rarely occurring more than two years after infection. ****(We use the term “remote infection” to describe infection preceding active TB by more than two years.)**** The vast burden of global TB is, therefore, from recently transmitted infection.