This site uses cookies.
Some of these cookies are essential to the operation of the site,
while others help to improve your experience by providing insights into how the site is being used.
For more information, please see the ProZ.com privacy policy.
Freelance translator and/or interpreter, Verified member
Data security
This person has a SecurePRO™ card. Because this person is not a ProZ.com Plus subscriber, to view his or her SecurePRO™ card you must be a ProZ.com Business member or Plus subscriber.
Affiliations
This person is not affiliated with any business or Blue Board record at ProZ.com.
Services
Translation, Editing/proofreading
Expertise
Specializes in:
Medical (general)
Biology (-tech,-chem,micro-)
Medical: Pharmaceuticals
Medical: Dentistry
Medical: Health Care
Also works in:
Medical: Cardiology
Education / Pedagogy
Genetics
Science (general)
More
Less
Rates
Portfolio
Sample translations submitted: 1
French to English: Holley A. Système olfactif et neurobiologie. Terrain, 47, 107-122. General field: Medical
Source text - French 14. Les récepteurs des odorants ?
Les récepteurs d’odorants appartiennent à une superfamille de protéines couplées à des protéines G (Buck & Axel 1991). Ce sont des protéines apparentées à l’opsine des photorécepteurs de la rétine ainsi qu’à d’autres récepteurs de neurotransmetteurs du système nerveux et de certaines hormones. Ils ont tous la même structure générale caractérisée par sept régions hydrophobes traversant la membrane, mais diffèrent les uns des autres par leurs séquences d’acides aminés, particulièrement variables dans certaines régions de la protéine, alors qu’elles sont bien conservées dans d’autres segments (Mombaerts 1999). Une molécule ne peut activer un récepteur que si elle trouve sur ce récepteur une région avec laquelle elle est en mesure d’échanger des liaisons disposées selon une géométrie tridimensionnelle adéquate. On pense que les régions « hypervariables » déterminent des sites de liaison ligand-récepteur (Singer & Shepherd 1994). La structure des récepteurs et leurs propriétés ne sont connues que de manière indirecte, elles sont inférées de la séquence des gènes qui codent ces récepteurs.
15. La transduction olfactive, c’est-à-dire l’amplification de l’énergie de liaison des odorants avec les récepteurs et sa conversion en signal électrique, implique une cascade de réactions enzymatiques dont la première étape est l’activation d’une protéine G. Il s’ensuit une série de réactions qui aboutissent à la production du « second messager ». La liaison de ce dernier à des canaux ioniques est à l’origine des courants électriques qui engendrent les signaux nerveux propagés par les axones des cellules sensorielles.
16. La sensibilité des cellules olfactives
Avant que ne soient découverts les récepteurs grâce aux travaux de biologie moléculaire, les réponses individuelles des neurones récepteurs avaient été longuement explorées par des méthodes électrophysiologiques (Gesteland et al. 1965 ; Holley et al. 1974 ; Sicard & Holley 1984 ; et plus tard Duchamp-Viret et al. 1999). Il a été trouvé que les cellules sensorielles avaient une sélectivité individuelle variable et, en moyenne, faible.
Translation - English 14. Odorant receptors?
Odorant receptors belong to a protein superfamily which couples to G proteins (Buck and Axel, 1991). They are related to the retinal photoreceptor protein opsin, as well as to other neurotransmitter receptors of the nervous system, and those of some hormones. They all have the same general structure characterised by seven hydrophobic transmembrane domains. They differ from each other in their amino acid sequences, which are particularly variable in some regions of the protein, whilst being highly conserved in other segments (Mombaerts, 1999). A receptor can only be activated by a molecule if it has a region bearing sites for ligand-receptor binding, arranged in an adequate three-dimensional configuration. It is thought that these ligand-receptor binding sites are specified by ‘hypervariable’ regions (Singer and Shepherd, 1994). Receptor structure and properties are only understood indirectly, being inferred from the receptor genetic coding sequence.
15. Olfactory transduction, that is the amplification of the energy generated by odorant-receptor binding and its conversion into an electrical signal, involves a cascade of enzymatic reactions, of which the first stage is activation of a G protein. This is followed by a series of reactions which culminate in the production of a second messenger. The binding of second messengers to ion channels generates the electrical currents which give rise to the neural signals transmitted by sensory cell axons.
16. The sensitivity of olfactory cells
Before odorant receptors were discovered by studies using molecular biological techniques, the individual responses of sensory neurons had been explored for a long time using electrophysiological methods (Gesteland et al., 1965; Holley et al., 1974., Sicard and Holley, 1984, and more recently, Duchamp-Viret et al., 1999). Sensory cells were found to have individual selectivities that were variable and on average, weak.
More
Less
Translation education
PhD - Manchester University
Experience
Years of experience: 10. Registered at ProZ.com: May 2013. Became a member: Mar 2015.
French to English (MA in Translation Studies) French to English (PhD (Neuroscience)) French to English (Diploma in French) French to English (BSc in Anatomy and Cell Biology)
Memberships
N/A
Software
Adobe Acrobat, Microsoft Excel, Microsoft Word, Powerpoint, Trados Studio
Translation of a wide range of specialized medical and life science texts by a PhD anatomist and neuroscientist with over eight years experience as a full-time medical translator
Services: Translation of medical and life science texts, French into English. Proofreading, revision of material written in English by non-native speakers.
Texts handled - Specialist scientific and clinical documents within the disciplines of Anatomy, Physiology, Neuroscience, Dentistry, Pharmaceuticals, Cell and Molecular Biology, Health Care, Life Sciences in general (e.g. journal articles, website materials, industry guides, patient leaflets, clinical trial reports, regulatory documents).
Academic Qualifications
MA in Translation Studies, Portsmouth University, distinction (2015)
Diploma in French, Open University (2012)
PhD (topic - cerebral hypoxia), Manchester University (2000)
BSc in Anatomy and Cell Biology, Sheffield University (1995), first class honours. I was awarded the Robert Barer prize in Anatomy.
I have expertise in a broad range of life science disciplines with specific experience in the translation of neuroscience, oncology, dentistry, pharmaceutical documents and dermatology.
Over 8 years experience as a full-time medical translator.
8 years experience as a professional anatomist in UK universities.
5 years experience as an academic researcher in the field of neuroscience in UK universities.
This user has earned KudoZ points by helping other translators with PRO-level terms. Click point total(s) to see term translations provided.
Member since Mar '15
