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Glossary entry

Spanish term or phrase:

Polimórfica blanco de la droga

English translation:

Polymorphic drug target

Added to glossary by David Russell
Aug 4, 2011 13:50
12 yrs ago
2 viewers *
Spanish term

Polimórfica blanco de la droga

Spanish to English Medical Medical: Pharmaceuticals Cancer drugs
This comes from a list of chemotherapy drugs produced in Spain, after the list it states:

Los prospectos del medicamento puede contener información sobre biomarcadores genómicos y puede describir:
Exposición al fármaco y la variabilidad de respuesta clínica
Riesgo de eventos adversos
Dosificación genotipo-específica
Mecanismos de acción de los fármacos
****Polimórfica blanco de la droga**** y los genes disposición
Proposed translations (English)
4 +1 Polymorphic drug target
3 Drug Target Polymorphism

Discussion

eski Sep 13, 2011:
Hi Ron Thanks for your comments. If it's any comfort to you; although at one time I had certain law enforcement experiences both in the military and later at a municipal level, the term was absolutely new to me and I only chose it based on the available links.
'Saludos!
eski :))
Ron Hartong PhD (X) Sep 12, 2011:
You're welcome David Your gratitude is much appreciated
Ron Hartong PhD (X) Aug 4, 2011:
Sorry David, I got carried away and suddenly called you Robert - no idea why.
Ron Hartong PhD (X) Aug 4, 2011:
Double work. Hi David (and Eski),
First of all, I think it will be difficult to clearly define the difference between 'Polymorphic drug target' and 'Drug Target Polymorphism' - it's semantics and in the end they mean the same thing.
Nevertheless 'Drug Target Polymorphism' gives 796 hits in Google, and 'Polymorphic drug target' gives only 5 hits.
I gave my agree to Eski though, because I found the English version of the text Robert is translating (see link below). In that text Eski's suggestion is used.
I guess (can't be sure though) that somebody 'plagiarized' the English text and translated it into (not realy correct) Spanish. Funnily, they later went to Robert to have it translated back into English again.

Here's the link:
http://www.fda.gov/drugs/scienceresearch/researchareas/pharm...

Hope the link helps you with the rest of the text you are translating, although it may be a bit late for that.

Proposed translations

+1
13 mins
Selected

Polymorphic drug target

Of all the current neurotransmitter drug targets, the 5-HT transporter promoter gene polymorphism (5-HTTLPR) is probably the most studied in relation to ...
Genomics > Table of Pharmacogenomic Biomarkers in Drug Labels
www.fda.gov › ... › Science & Research (Drugs) › Research Areas - Cached27 Jul 2011 – Drug labels may contain information on genomic biomarkers and can describe ... of drug action; Polymorphic drug target and disposition genes ...
Pharmacogenetics of analgesics: toward the individualization of ...
www.ncbi.nlm.nih.gov/pubmed/18597654by V Rollason - 2008 - Cited by 22 - Related articles
Whereas polymorphic drug-metabolizing enzymes and drug transporters may affect the pharmacokinetics of drugs, polymorphic drug targets and disease-related ...

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Note added at 14 mins (2011-08-04 14:04:57 GMT)
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Clinical implications of CYP2D6 genetic polymorphism during ...
www.ncbi.nlm.nih.gov/pubmed/17168842by P Dorado - 2006 - Cited by 15 - Related articles
Curr Drug Targets. 2006 Dec;7(12):1671-80. Clinical implications of CYP2D6 ...
Show more results from nih.gov
Polymorphism (materials science) - Wikipedia, the free encyclopedia
en.wikipedia.org/wiki/Polymorphism_(materials_science) - CachedPolymorphism in drugs can also have direct medical implications. Medicine is often administered orally as a crystalline solid and dissolution rates depend ...
[PDF] Pharmacogenetics: an opportunity for a safer and more efficient ...
faculty.ksu.edu.sa/hisham/Documents/.../Pharmacogenetics.pdfFile Format: PDF/Adobe Acrobat - Quick View
by M INGELMAN-SUNDBERG - 2001 - Cited by 166 - Related articles
drug treatment of asthma where the efficiency can be severely enhanced by predictive genotyping of the drug targets. In addition, certain polymorphic genes ...
PHARMACOGENETIC AND TUMOUR DRUGS - IFCC.ORG
www.ifcc.org/index.asp?... - Cached12.4 Polymorphic drug target. Polymorphisms in drug targets are also an important area for pharmacogenetic studies, since over-expression or ...

Saludos
eski :))

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Note added at 3413 days (2020-12-07 15:12:18 GMT) Post-grading
--------------------------------------------------

Thanks again, David! - eski :)
Peer comment(s):
agree Ron Hartong PhD (X) : Polymorphic drug target would have been blanco polimórfico de la droga in Spanish; Nevertheless, I agree with you for reasons I'll try to explain in the discussion.
1 hr
Thanks Ron; I'm sure you know more on the subject than I do: 'saludos', eski :))
Something went wrong...
4 KudoZ points awarded for this answer. Comment: "A little late in the day, but thanks!"
10 mins

Drug Target Polymorphism

I am not a 100% sure, because I think in Spanish it would be more correct to say 'polimorfismo'; I guess that 'polimórfica' is meant as short for 'secuencia polimórfica'.

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Note added at 1 hr (2011-08-04 15:38:17 GMT)
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I just noticed that the link I gave doesn't work.
If you Google (no quotes)
Drug Target Polymorphisms - Medscape
the first hit you get will take you to the article.
Reference:

http://www.medscape.com/viewarticle/725158_4

Something went wrong...
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