Nov 16, 2005 12:07
18 yrs ago
1 viewer *
German term
ohne Trend mit anschließendem Rückgang
German to English
Medical
Medical: Pharmaceuticals
Results of clinical trial of test drug
Wie in den Vorgruppen waren Transaminasenwerte (hier bei 2 Probanden) grenwertig bis leicht erhöht (ASAT bis 1,6-fach, ALAT bis 1,6-fach, gGT bis 1,7-fach), jedoch ohne Trend mit anschließendem Rückgang.
This concerns the blood values of human subjects in a clinical trial. I'm stumped by the last part of this sentence. Does this mean that the higher values did not represent a trend and fell back subsequently? Would greatly appreciate some expert advice here.
This concerns the blood values of human subjects in a clinical trial. I'm stumped by the last part of this sentence. Does this mean that the higher values did not represent a trend and fell back subsequently? Would greatly appreciate some expert advice here.
Proposed translations
(English)
| 4 +1 | without a trend showing subsequent normalization / decrease |
MMUlr
|
| 4 | without trend and fell back subsequently |
rainerc (X)
|
| 2 | no evidence of disease trend with subsequent drop in |
Jonathan MacKerron
|
Proposed translations
+1
13 mins
German term (edited):
ohne Trend mit anschlie�endem R�ckgang
Selected
without a trend showing subsequent normalization / decrease
see "subsequent normalization" related to liver enzymes:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...
HTH :-)
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Note added at 26 mins (2005-11-16 12:33:31 GMT)
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"ohne Trend" means a sort of statistical statement (trend towards significance between groups, or not?).
See use of "without a trend" related to stratified age groups in this article (page 1, bottom left column):
http://www.ajtmh.org/cgi/reprint/69/3/288
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Note added at 1 day 15 hrs 32 mins (2005-11-18 03:40:04 GMT)
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IMO there is still a need to clarify this even more. I see two parts of your question:
a. What is "zurückgehend" - the answer: the elevated liver enzyme values are decreasing, normalizing
b. What does "ohne Trend" mean in this context?
(The "und" - "und mit anschließendem ..." would make the sentence clearer, as Anne wrote above.)
answer to b.:
Evaluating the cases demonstrating these elevated values, investigators war not able to find any statistical trend or an indication for a specific correlation with another variable (maybe to the therapy they had received before the increase? The details of this study are needed to identify this/these other "variable(s)".)
e.g., the article above, my second URL:
Here the parameter observed was the positive HBsAG test in Vietnamese people. They stratified the sample in several age groups and did not find any trend towards a specific correlation between age group and positive HBsAG.
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&d...
HTH :-)
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Note added at 26 mins (2005-11-16 12:33:31 GMT)
--------------------------------------------------
"ohne Trend" means a sort of statistical statement (trend towards significance between groups, or not?).
See use of "without a trend" related to stratified age groups in this article (page 1, bottom left column):
http://www.ajtmh.org/cgi/reprint/69/3/288
--------------------------------------------------
Note added at 1 day 15 hrs 32 mins (2005-11-18 03:40:04 GMT)
--------------------------------------------------
IMO there is still a need to clarify this even more. I see two parts of your question:
a. What is "zurückgehend" - the answer: the elevated liver enzyme values are decreasing, normalizing
b. What does "ohne Trend" mean in this context?
(The "und" - "und mit anschließendem ..." would make the sentence clearer, as Anne wrote above.)
answer to b.:
Evaluating the cases demonstrating these elevated values, investigators war not able to find any statistical trend or an indication for a specific correlation with another variable (maybe to the therapy they had received before the increase? The details of this study are needed to identify this/these other "variable(s)".)
e.g., the article above, my second URL:
Here the parameter observed was the positive HBsAG test in Vietnamese people. They stratified the sample in several age groups and did not find any trend towards a specific correlation between age group and positive HBsAG.
4 KudoZ points awarded for this answer.
Comment: "Muchos Gracias"
3 mins
German term (edited):
ohne Trend mit anschlie�endem R�ckgang
without trend and fell back subsequently
.
1 hr
Jonathan MacKerron
Native in English
Specializes in field
Retired as of Jan 2019!
Native in: English
Works in: German to English, French to English
Related KudoZ points
:
180
German term (edited):
ohne Trend mit anschlie�endem R�ckgang
no evidence of disease trend with subsequent drop in
another option
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Note added at 1 hr 33 mins (2005-11-16 13:41:04 GMT)
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no evidence of disease trend, nor subsequent drop in
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Note added at 1 hr 33 mins (2005-11-16 13:41:04 GMT)
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no evidence of disease trend, nor subsequent drop in
Discussion