Glossary entry (derived from question below)
English term or phrase:
amenable mutations
Serbian translation:
mutacije koje (dobro) reaguju (na tretman / lek)
Added to glossary by
Svetomir Mijovic
Nov 20, 2022 12:57
1 yr ago
13 viewers *
English term
amenable mutations
English to Serbian
Medical
Medical: Pharmaceuticals
pharmacological tests
In one or more embodiments, mutant forms of α-Gal A are considered to be amenable to migalastat are defined as showing a relative increase (+10 µM migalastat) of >1.20-fold and an absolute increase (+ 10 µM migalastat) of ≥ 3.0% wild-type (WT) when the mutant form of α-Gal A is expressed in HEK-293 cells (referred to as the "HEK assay") according to Good Laboratory Practice (GLP)-validated in vitro assay (GLP HEK or Migalastat Amenability Assay). Such mutations are also referred to herein as "HEK assay amenable" mutations....
HEK assay amenable mutations include at least those mutations listed in a pharmacological reference table (e.g., the ones recited in the U.S. or International Product labels for a migalastat product such as GALAFOLD®). As used herein, "pharmacological reference table" refers to any publicly accessible written or electronic record, included in either the product label within the packaging of a migalastat product (e.g., GALAFOLD®) or in a website accessible by health care providers, that conveys whether a particular mutation or variant is responsive to migalastat (e.g., GALAFOLD®) PC therapy, and is not necessarily limited to written records presented in tabular form.
HEK assay amenable mutations include at least those mutations listed in a pharmacological reference table (e.g., the ones recited in the U.S. or International Product labels for a migalastat product such as GALAFOLD®). As used herein, "pharmacological reference table" refers to any publicly accessible written or electronic record, included in either the product label within the packaging of a migalastat product (e.g., GALAFOLD®) or in a website accessible by health care providers, that conveys whether a particular mutation or variant is responsive to migalastat (e.g., GALAFOLD®) PC therapy, and is not necessarily limited to written records presented in tabular form.
Proposed translations
(Serbian)
5 | mutacije koje (dobro) reaguju (na tretman / lek) | Milan Nesic |
Proposed translations
8 mins
Selected
mutacije koje (dobro) reaguju (na tretman / lek)
"An amenable mutation is a genetic change or variant that a person may have that is responsive - amenable - to treatment."
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Note added at 13 hrs (2022-11-21 01:57:27 GMT)
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Još bolji prevod za "amenable" bi bio "responzivne".
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Note added at 13 hrs (2022-11-21 01:59:04 GMT)
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"responzivne mutacije"
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Note added at 13 hrs (2022-11-21 01:57:27 GMT)
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Još bolji prevod za "amenable" bi bio "responzivne".
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Note added at 13 hrs (2022-11-21 01:59:04 GMT)
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"responzivne mutacije"
4 KudoZ points awarded for this answer.
Comment: "Hvala!"
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