English to French Tech/Engineering Patents (in a patent) An oral dosage form

the invention provides a method of preventing the abuse of an oral dosage form of an opioid agonist, comprising:
coating a non-releasing membrane onto an opioid-antagonist formulation, and coating an opioid-agonist layer onto the non-releasing membrane to form an oral dosage form;
wherein the opioid-antagonist formulation comprises a therapeutically effective amount of an opioid antagonist, the non-releasing membrane comprises at least one water-retardant polymer that is a non-ionic poly(ethyl acrylate-co-methyl methacrylate),

the present invention provides a novel oral dosage form of a therapeutically effective amount of an opioid antagonist which does
not release when orally administered to a human being, but which does release upon a physical alteration of the oral dosage form.

if the oral dosage form o f the invention is physically altered in any way, such as by crushing or grinding of the oral dosage form, then the therapeutically effective amount o f the opioid antagonist will be released. That is, as the non-releasing membrane o f the oral dosage form is rendered ineffective by physical alteration, the opioid antagonist will no longer be effectively coated by the non-releasing membrane and the therapeutically effective amount of the opioid antagonist will thereby be released