Dec 14, 2022 22:04
1 yr ago
22 viewers *
English term

backfill

English to Arabic Medical Medical (general)
For Part 2A subjects with CRPC enrolled at the highest dose and those enrolled as backfill in selected dosing cohorts, please make your choices and initial each statement below:

Proposed translations

+1
12 mins

تكملة للعدد

أعتقد أنهم تكملة لعدد الأشخاص المحدد في العينة
Peer comment(s):

agree Mohammad Najim
20 hrs
شكرًا جزيلًا
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39 mins

أُعطوا جرعات أقل من المستهدفة

أُعطوا جرعات أقل من المستهدفة
أُعطوا جرعات أقل من الجرعة التي يستهدفها البحث/ تستهدفها الدراسة
kindly, find below the definition of backfill in this medical context.

The use of backfill in early phase dose-finding trials is a relatively recent practice. It consists of assigning patients to dose levels below the level where the study is at. The main reason for backfilling is to collect additional pharmacokinetic, pharmacodynamic and response data, in order to assess whether a plateau may exist on the dose-efficacy curve.
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